| 邓茗月,叶翆红,邹文生,李卫华.电场增强锰掺杂硫化锌量子点室温磷光的
肝素钠多糖检测[J].安徽建筑大学学报,2019,27(1):76-82 |
| 电场增强锰掺杂硫化锌量子点室温磷光的
肝素钠多糖检测 |
| Detection of Heparin Sodium Polysaccharide by Electric Field Enhanced |
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| DOI： |
| 中文关键词: 锰掺杂硫化锌量子点 八胺丙基寡聚硅 室温磷光 肝素钠 |
| 英文关键词: Mn capped ZnS QDs (Mn-ZnS QDs),OA-POSS,Room-temperature phosphorescence (RTP),Heparin |
| 基金项目:安徽省重点研发项目(1704a0902006)；安徽省科技重大专项(17030801028)；安徽省高校自然研究项目(KJ2018A0513) |
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| 中文摘要: |
| 文章报道了一种基于锰掺杂硫化锌量子点(Mn-ZnS QDs)的室温磷光(RTP)方法检测肝素钠。荷正电的
八胺丙基寡聚硅(OA-POSS)与荷负电的半胱氨酸包裹的Mn-ZnS QDs 在水溶液中通过静电作用自组装成纳米复
合物。Mn-ZnS QDs 在电场作用下缩短了点间距离，修复了表面缺陷、有效诱导QDs 的激发与引起表面Mn2+
重排，增强了Mn2+的RTP 发射。当荷更高负电的肝素钠加入纳米复合物体系中，发生三组分竞争作用，旧的
纳米复合物分解，新的OA-POSS 与肝素钠聚集复合物形成，导致了Mn-ZnS QDs 的RTP 逐渐衰减，这种衰
减的RTP 信号被用来检测肝素钠。衰减的RTP 强度(ΔP)和肝素钠浓度在2.5 到70 μM 范围内存在着很好的线
性相关关系(R=0.991)，检测限为2.0 μM，5 次测定的相对标准偏差为6.9%。本文提出的方法非常适合选择性
探测复杂样品中肝素钠。 |
| 英文摘要: |
| Herein a room-temperature phosphorescence (RTP) approach for the detection of heparin based on Mn capped
ZnS QDs (Mn-ZnS QDs) was reported. The nanocompsites were formed by electrostatic interaction in solution between
OA-POSS positively charged and L-cysteine coated Mn-ZnS QDs negatively charged. The distance among QDs was shortened
by electric field，and then the defects on the surface of QDs were repaired，the excitation of QDs was effectively
induced and Mn2+ on the surface of QDs were rearranged，resulting in the enhancement of RTP of Mn2+. When heparin
with much higher negative charge was added into the above nanocompsites system，competitive effect among three component
happened. Accordingly，old nanocompsites were decomposed and，new ones took shape between OA-POSS and
heparin，causing the decayed RTP，which was taken advantage of the detection of heparin. Mn-ZnS QDs showed a very good linearity in the range of 2.5-75 μM heparin with detection limit down to 2 μM and RSD of 6.9% (n = 5). The
proposed method is well-suited for selective detection of the heparin in complex samples. |
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